Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 7/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524167 | 0.81 | S1PR1 (0.44) | CYP19A1CYP11B1CYP11B2CYP2A6CYP2B6 | |
| SCHEMBL9662907 | 0.78 | CCNT1 (0.46) | CYP19A1CYP11B1CYP11B2ALDH1A1KDM4E | |
| SCHEMBL9663727 | 0.72 | CYP11B1 (0.54) | CYP19A1CYP11B1CYP11B2ALDH1A1TBXAS1 | |
| SCHEMBL18136723 | 0.71 | GAA (0.52) | GAAALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL22862569 | 0.71 | DRD2 (0.42) | GAAALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL22862828 | 0.71 | HSD17B10 (0.43) | GAAALDH1A1NPC1HSD17B10HPGD | |
| SCHEMBL15833718 | 0.71 | GAA (0.52) | GAAALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL31144588 | 0.71 | GAA (0.52) | GAAALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL11481138 | 0.70 | CYP11B1 (0.57) | CYP19A1CYP11B1CYP11B2CYP2A6CYP2B6 | |
| Hydrochloric Acid SCHEMBL11167000 | 0.69 | CYP2B6 (0.45) | CYP19A1CYP11B1CYP11B2CYP2A6CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260744-B1 | (1H-IMIDAZOL-1-YLMETHYL) SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |
| US-4859684-A | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-08-22 | — | — | US | disclosed |
| EP-0260744-A2 | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-03-23 | — | — | EP | disclosed |