Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9664756 | 0.78 | CYP19A1 (0.54) | CYP19A1CYP11B1CYP11B2TBXAS1ADRA2C | |
| SCHEMBL9524167 | 0.78 | S1PR1 (0.44) | CYP19A1CYP11B1CYP11B2TBXAS1S1PR1 | |
| SCHEMBL9665018 | 0.78 | CYP19A1 (0.44) | KDM4EALDH1A1GFERCYP19A1CYP11B1 | |
| SCHEMBL9664994 | 0.77 | CYP19A1 (0.52) | CYP19A1CYP11B1CYP11B2TBXAS1ADRA2C | |
| SCHEMBL9662930 | 0.76 | CYP19A1 (0.54) | MAPTCYP19A1CYP11B1CYP11B2TBXAS1 | |
| SCHEMBL27359733 | 0.76 | CDK9 (0.54) | CCNT1CDK9KDM4EALDH1A1MAPT | |
| SCHEMBL9664945 | 0.72 | CYP2B6 (0.44) | CYP19A1CYP11B1CYP11B2TBXAS1CYP2A6 | |
| SCHEMBL19698020 | 0.72 | CDK9 (0.58) | CCNT1CDK9KDM4EALDH1A1MAPT | |
| SCHEMBL9663766 | 0.71 | CYP11B1 (0.44) | MAPTCYP19A1CYP11B1CYP11B2TBXAS1 | |
| SCHEMBL17378350 | 0.71 | CYP11B2 (0.44) | CYP19A1CYP11B1CYP11B2ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260744-B1 | (1H-IMIDAZOL-1-YLMETHYL) SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-16 | — | — | EP | disclosed |
| US-4859684-A | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives and use thereof in treating androgen dependent disorders | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-08-22 | — | — | US | disclosed |
| EP-0260744-A2 | (1H-imidazol-1-ylmethyl) substituted benzimidazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-03-23 | — | — | EP | disclosed |