Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9665018 | 0.81 | CYP19A1 (0.44) | CYP19A1CYP11B1CYP11B2CYP2A6CYP2B6 | |
| SCHEMBL9662907 | 0.78 | CCNT1 (0.46) | S1PR1CYP19A1CYP11B1CYP11B2CYP2A6 | |
| SCHEMBL9525410 | 0.77 | CYP11B1 (0.51) | CYP19A1CYP11B1CYP11B2CYP2A6CYP2B6 | |
| SCHEMBL9707231 | 0.77 | CYP11B1 (0.51) | CYP19A1CYP11B1CYP11B2CYP2A6CYP2B6 | |
| Hydrochloric Acid SCHEMBL9527151 | 0.76 | CYP11B1 (0.50) | CYP19A1CYP11B1CYP11B2CYP2A6CYP2B6 | |
| SCHEMBL9527191 | 0.74 | CYP19A1 (0.52) | CYP19A1CYP11B1CYP11B2CYP2A6CYP2B6 | |
| SCHEMBL9523481 | 0.73 | CYP11B1 (0.52) | CYP19A1CYP11B1CYP11B2TBXAS1CYP17A1 | |
| SCHEMBL9524490 | 0.73 | CYP11B1 (0.60) | CYP19A1CYP11B1CYP11B2CYP2A6CYP2B6 | |
| SCHEMBL9527653 | 0.71 | CYP19A1 (0.46) | CYP19A1CYP11B1CYP11B2CYP2A6CYP2B6 | |
| SCHEMBL9527239 | 0.71 | SLC9A1 (0.49) | CYP19A1CYP11B1CYP11B2CYP2A6CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293978-B1 | (1H-AZOL-1-YLMETHYL)SUBSTITUTED BENZOTRIAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-09-15 | — | — | EP | disclosed |
| US-5039677-A | Estrogen inhibitor | JANSSEN PHARMACEUTICA N.V. (CA) | 1991-08-13 | — | — | US | disclosed |
| US-4943574-A | AROMATASE INHIBITORS, ESTROGEN DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |
| EP-0293978-A2 | (1H-azol-1-ylmethyl)substituted benzotriazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-12-07 | — | — | EP | disclosed |