Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667720 | 0.96 | PDE4B (0.40) | USP2ALDH1A1KDM4ETSHRGAA | |
| SCHEMBL7236050 | 0.82 | ALDH1A1 (0.45) | USP2ALDH1A1KDM4ETSHRGAA | |
| SCHEMBL7236923 | 0.81 | ALDH1A1 (0.40) | USP2ALDH1A1KDM4ETSHRGAA | |
| SCHEMBL9667216 | 0.79 | KMT2A (0.46) | USP2ALDH1A1KDM4ETSHRGAA | |
| SCHEMBL9666120 | 0.78 | HPGD (0.45) | ALDH1A1KDM4ETSHRTP53MAPT | |
| SCHEMBL2743830 | 0.76 | ALDH1A1 (0.47) | USP2ALDH1A1KDM4ETSHRGAA | |
| SCHEMBL9665440 | 0.75 | TP53 (0.44) | ATMTP53HTTL3MBTL1 | |
| SCHEMBL9667378 | 0.75 | CASP3 (0.48) | USP2ALDH1A1KDM4ETSHRGAA | |
| SCHEMBL10746773 | 0.75 | ALDH1A1 (0.40) | USP2ALDH1A1KDM4ETSHRGAA | |
| SCHEMBL9667195 | 0.75 | USP2 (0.38) | USP2ALDH1A1KDM4ETSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0181136-B1 | OXINDOLE ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| US-4686224-A | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1987-08-11 | — | — | US | disclosed |
| EP-0181136-A2 | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1986-05-14 | — | — | EP | disclosed |