Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667216 | 0.91 | KMT2A (0.46) | CASP3USP2ALDH1A1KDM4EGAA | |
| SCHEMBL9667758 | 0.85 | USP2 (0.43) | CASP3USP2ALDH1A1KDM4EGAA | |
| SCHEMBL9666290 | 0.84 | USP2 (0.42) | USP2ALDH1A1KDM4EGAATSHR | |
| SCHEMBL9668245 | 0.84 | USP2 (0.42) | USP2ALDH1A1KDM4EGAATSHR | |
| SCHEMBL9667449 | 0.81 | MEN1 (0.46) | CASP3USP2ALDH1A1KDM4EGAA | |
| SCHEMBL9665452 | 0.79 | MAPT (0.48) | GAACYP1A2CYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL7236836 | 0.76 | USP2 (0.43) | USP2ALDH1A1KDM4EGAATSHR | |
| SCHEMBL7236050 | 0.75 | ALDH1A1 (0.45) | USP2ALDH1A1KDM4EGAATSHR | |
| SCHEMBL9665346 | 0.75 | USP2 (0.40) | USP2ALDH1A1KDM4EGAATSHR | |
| SCHEMBL7235333 | 0.75 | USP2 (0.43) | USP2ALDH1A1KDM4EGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0181136-B1 | OXINDOLE ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| US-4686224-A | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1987-08-11 | — | — | US | disclosed |
| EP-0181136-A2 | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1986-05-14 | — | — | EP | disclosed |