Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9212567 | 0.75 | CA1 (0.33) | — | |
| SCHEMBL9212573 | 0.75 | CA1 (0.33) | — | |
| SCHEMBL10922159 | 0.75 | KDM4E (0.43) | KDM4EPKMP2RX4GAAMAPT | |
| SCHEMBL10925551 | 0.67 | KDM4E (0.47) | KDM4EPKMP2RX4GAAMAPT | |
| SCHEMBL10919330 | 0.67 | KDM4E (0.39) | KDM4EPKMGAAMAPTKIF11 | |
| SCHEMBL9644068 | 0.66 | PDK2 (0.37) | KDM4EPKMMAPTKIF11 | |
| SCHEMBL27390499 | 0.66 | KDM4E (0.46) | KDM4EPKMGAAMAPTKIF11 | |
| SCHEMBL5837474 | 0.65 | KDM4E (0.39) | KDM4EPKMP2RX4GAAMAPT | |
| SCHEMBL18403739 | 0.65 | OXTR (0.32) | KDM4EPKM | |
| SCHEMBL13096618 | 0.64 | KIF11 (0.48) | MAPTKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0264183-B1 | DERIVATIVES OF 5-METHYL-10,11-DIHYDRO-5H-DIBENZO-(A,D) CYCLOHEPTEN-5,10-IMINE | MERCK & CO. INC. (US) | 1992-01-15 | — | — | EP | disclosed |
| EP-0264183-A1 | Derivatives of 5-methyl-10,11-dihydro-5H-dibenzo-(a,d) cyclohepten-5,10-imine | MERCK & CO. INC. (US) | 1988-04-20 | — | — | EP | disclosed |