Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10688684 | 0.94 | KMT2A (0.31) | KMT2A | |
| SCHEMBL10696071 | 0.93 | SLC6A1 (0.31) | — | |
| SCHEMBL10691939 | 0.93 | ABCB1 (0.35) | TSHRSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL10695887 | 0.87 | ABCB1 (0.34) | TSHRSMN1; SMN2LMNAMEN1MAPT | |
| SCHEMBL9668732 | 0.86 | ABCB1 (0.42) | TSHRSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL9666610 | 0.86 | ABCB1 (0.34) | TSHRSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL10693262 | 0.86 | ABCB1 (0.34) | TSHRSMN1; SMN2LMNAMEN1MAPT | |
| SCHEMBL10697691 | 0.86 | — | — | |
| SCHEMBL9666976 | 0.85 | ALDH1A1 (0.34) | TSHRSMN1; SMN2LMNAMEN1ALDH1A1 | |
| SCHEMBL10694259 | 0.84 | EBP (0.35) | SMN1; SMN2LMNAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220104-B1 | 5-AMINO-PENTANENITRILE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 1992-04-15 | — | — | EP | claimed |
| US-4792559-A | 1,2,3,4-tetrahydroquinoline substituted 5-aminopentanenitrile compounds and their use as calcium modulators | ADIR ET COMPAGNIE (FR) | 1988-12-20 | — | — | US | claimed |
| US-4792559-A | 1,2,3,4-tetrahydroquinoline substituted 5-aminopentanenitrile compounds and their use as calcium modulators | ADIR ET COMPAGNIE (FR) | 1988-12-20 | — | — | US | disclosed |