Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.41 |
| ▸ | TLR4 | O00206 | 1/20 | 0.36 |
| ▸ | USP5 | P45974 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4038640 | 0.79 | NFE2L2 (0.31) | — | |
| SCHEMBL2911666 | 0.77 | EDNRA (0.35) | SMN1; SMN2 | |
| SCHEMBL2912112 | 0.76 | GLRA1 (0.32) | PTPN1POLB | |
| SCHEMBL4092709 | 0.76 | TP53 (0.31) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2909214 | 0.75 | SCN8A (0.30) | — | |
| SCHEMBL2908212 | 0.75 | ACHE (0.32) | RAB9A | |
| SCHEMBL2910809 | 0.74 | MAPT (0.39) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2910922 | 0.74 | TDP2 (0.34) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2912111 | 0.74 | — | — | |
| SCHEMBL2913727 | 0.73 | CACNA1B (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273647-B1 | COUMARAN DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1992-03-11 | — | — | EP | disclosed |
| US-4857516-A | Coumaran derivatives and their pharmaceutical use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-08-15 | — | — | US | disclosed |
| EP-0273647-A1 | Coumaran derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1988-07-06 | — | — | EP | disclosed |