Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TDP2 | O95551 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667484 | 0.85 | TDP2 (0.48) | ALDH1A1L3MBTL1MAPTTDP2MEN1 | |
| SCHEMBL10738796 | 0.76 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1MAPTTDP2MEN1 | |
| SCHEMBL7218237 | 0.75 | MAPT (0.74) | ALDH1A1L3MBTL1MAPTTDP2MEN1 | |
| SCHEMBL11478104 | 0.74 | AKR1C3 (0.39) | ALDH1A1L3MBTL1MAPTKMT2APOLB | |
| SCHEMBL11789979 | 0.73 | TDP2 (0.68) | ALDH1A1L3MBTL1MAPTTDP2MEN1 | |
| SCHEMBL10898266 | 0.70 | MEN1 (0.41) | ALDH1A1L3MBTL1MEN1KMT2AMAPK1 | |
| SCHEMBL10897713 | 0.69 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1MEN1KMT2ACYP1A2 | |
| SCHEMBL27619302 | 0.68 | ALDH1A1 (0.62) | ALDH1A1L3MBTL1MAPTTDP2MEN1 | |
| SCHEMBL195278 | 0.67 | TSHR (0.75) | ALDH1A1L3MBTL1MEN1KMT2ACYP1A2 | |
| SCHEMBL29619268 | 0.67 | TSHR (0.75) | ALDH1A1L3MBTL1MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0181136-B1 | OXINDOLE ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| US-4686224-A | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1987-08-11 | — | — | US | disclosed |
| US-4644005-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1987-02-17 | — | — | US | disclosed |
| EP-0181136-A2 | Oxindole antiinflammatory agents | PFIZER INC. (US) | 1986-05-14 | — | — | EP | disclosed |