Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | QPCT | Q16769 | 10/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 6/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL962539 | 0.89 | CYP1A2 (0.36) | ALDH1A1GAAMAPT | |
| SCHEMBL961808 | 0.82 | PSEN1 (0.34) | JUNMAPK10PSEN1PSEN2APH1B | |
| SCHEMBL960711 | 0.79 | PSEN1 (0.44) | ALDH1A1GAAMAPTQPCTPSEN1 | |
| SCHEMBL963443 | 0.77 | KIT (0.35) | JUNMAPK10ALDH1A1GAAMAPT | |
| SCHEMBL961727 | 0.77 | PSEN1 (0.37) | JUNMAPK10PSEN1PSEN2APH1B | |
| SCHEMBL961139 | 0.76 | ALDH1A1 (0.34) | ALDH1A1GAAMAPTQPCTPSEN1 | |
| SCHEMBL966637 | 0.76 | KDM4E (0.41) | ALDH1A1GAAMAPTPSEN1PSEN2 | |
| SCHEMBL12918204 | 0.73 | HTR3E (0.33) | JUNMAPK10 | |
| Iodide SCHEMBL963646 | 0.72 | NOS3 (0.32) | JUNMAPK10 | |
| SCHEMBL25347050 | 0.70 | MAPT (0.39) | ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379553-B1 | BICYCLIC COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL MYERS SQUIBB CO (US) | 2013-06-26 | — | — | EP | disclosed |
| US-8349880-B2 | Bicyclic compounds for the reduction of beta-amyloid production | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-01-08 | — | — | US | disclosed |
| EP-2379553-A1 | BICYCLIC COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | Bristol-Myers Squibb Company (US) | 2011-10-26 | — | — | EP | disclosed |
| US-20110015175-A1 | Bicyclic Compounds for the Reduction of Beta-Amyloid Production | BRISTOL-MYERS SQUIBB COMPANY | 2011-01-20 | — | — | US | disclosed |
| WO-2010083141-A1 | BICYCLIC COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110015175-A1 | Bicyclic Compounds for the Reduction of Beta-Amyloid Production | APP, BACE1, APBA1 | JUN 2664/4885MAPK10 2811/4885ALDH1A1 1819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.