Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD1 | P21728 | 3/20 | 0.36 |
| ▸ | DRD5 | P21918 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | CDC42 | P60953 | 1/20 | 0.34 |
| ▸ | RAC1 | P63000 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9667529 | 0.94 | GAA (0.41) | ALOX5AKR1C3AKR1C2PTGS1AKR1C1 | |
| SCHEMBL9667686 | 0.90 | PTGS2 (0.39) | ALOX5AKR1C3AKR1C2PTGS1AKR1C1 | |
| SCHEMBL9666512 | 0.87 | GAA (0.41) | KMT2ADRD2DRD1DRD5DRD3 | |
| SCHEMBL9666523 | 0.87 | ALOX5 (0.38) | ALOX5AKR1C3AKR1C2PTGS1AKR1C1 | |
| SCHEMBL9667687 | 0.87 | HCN4 (0.34) | DRD1DRD5DRD4TSHR | |
| Hydrochloric Acid SCHEMBL9667804 | 0.86 | GAA (0.41) | KMT2ADRD2DRD1DRD5DRD3 | |
| Hydrochloric Acid SCHEMBL9665757 | 0.86 | ALOX5 (0.38) | ALOX5AKR1C3AKR1C2PTGS1AKR1C1 | |
| SCHEMBL10693977 | 0.85 | ALOX5 (0.40) | ALOX5AKR1C3AKR1C2PTGS1AKR1C1 | |
| SCHEMBL9667729 | 0.83 | GAA (0.38) | DRD2DRD1DRD5DRD3DRD4 | |
| SCHEMBL10521534 | 0.82 | ALOX5 (0.38) | ALOX5AKR1C3AKR1C2PTGS1AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259793-B1 | NAPHTHYL DERIVATIVES, MEDICAMENTS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1992-07-01 | — | — | EP | disclosed |
| US-4871735-A | HYPOTENSIVE, ANTIISCHEMIC AGENTS | DR. KARL THOMAE GMBH | 1989-10-03 | — | — | US | disclosed |
| EP-0259793-A1 | Naphthyl derivatives, medicaments containing them and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |