Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | ADH1B | P00325 | 1/20 | 0.35 |
| ▸ | ADH1C | P00326 | 1/20 | 0.35 |
| ▸ | ADH1A | P07327 | 1/20 | 0.35 |
| ▸ | ADH4 | P08319 | 1/20 | 0.35 |
| ▸ | ADH7 | P40394 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7879516 | 0.77 | METAP1 (0.41) | METAP1ADH1BADH1CADH1AADH4 | |
| SCHEMBL9668100 | 0.76 | METAP1 (0.43) | METAP1ADH1BADH1CADH1AADH4 | |
| SCHEMBL6564265 | 0.74 | METAP1 (0.38) | METAP1ADH1BADH1CADH1AADH4 | |
| SCHEMBL16933893 | 0.72 | METAP1 (0.45) | METAP1CYP1A2SIGMAR1HPGD | |
| SCHEMBL28022207 | 0.69 | CYP1A2 (0.42) | METAP1CYP1A2SIGMAR1 | |
| SCHEMBL8022645 | 0.69 | METAP1 (0.47) | METAP1CYP1A2SIGMAR1HPGD | |
| SCHEMBL18526419 | 0.68 | METAP1 (0.47) | METAP1ADH1BADH1CADH1AADH4 | |
| SCHEMBL14104894 | 0.68 | METAP1 (0.52) | METAP1ADH1BADH1CADH1AADH4 | |
| SCHEMBL10069252 | 0.68 | METAP1 (0.52) | METAP1ADH1BADH1CADH1AADH4 | |
| SCHEMBL4993524 | 0.68 | METAP1 (0.40) | METAP1ADH1BADH1CADH1AADH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279298-B1 | TRICYCLIC TRIAZOLOPYRIMIDINE DERIVATIVES | DAIICHI SEIYAKU CO., LTD. (JP) | 1992-01-15 | — | — | EP | disclosed |
| US-4898943-A | Tricyclic triazolopyrimidine derivatives | DAIICHI SEIYAKU CO., LTD. (JP) | 1990-02-06 | — | — | US | disclosed |
| EP-0279298-A1 | Tricyclic triazolopyrimidine derivatives | DAIICHI SEIYAKU CO., LTD. (JP) | 1988-08-24 | — | — | EP | disclosed |