Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.50 |
| ▸ | METAP1 | P53582 | 2/20 | 0.50 |
| ▸ | CBFB | Q13951 | 2/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9665946 | 0.88 | NPC1 (0.43) | METAP2METAP1CBFBKMT2ANPC1 | |
| SCHEMBL9665954 | 0.88 | KMT2A (0.52) | METAP2METAP1CBFBPDE10AMAPT | |
| SCHEMBL9666986 | 0.85 | KMT2A (0.47) | METAP2METAP1CBFBPDE10AMAPT | |
| SCHEMBL9666973 | 0.83 | NPC1 (0.51) | METAP2METAP1MAPTNPC1RAB9A | |
| SCHEMBL9667019 | 0.81 | RAB9A (0.41) | METAP2METAP1CBFBMAPTKMT2A | |
| SCHEMBL9667212 | 0.81 | RAB9A (0.54) | CBFBPDE10AKMT2AMEN1NPC1 | |
| SCHEMBL9667203 | 0.81 | SMN1; SMN2 (0.46) | MAPTKMT2AMEN1TDP1NPC1 | |
| SCHEMBL9667979 | 0.79 | CBFB (0.54) | METAP2CBFBPDE10ADRD4 | |
| SCHEMBL9667049 | 0.79 | CBFB (0.43) | CBFBPDE10ANPC1RAB9AKDM4E | |
| SCHEMBL9667030 | 0.78 | RIPK1 (0.58) | METAP1MAPTKMT2AMEN1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0234980-B1 | 2-BENZIMIDAZOLYLALKYLTHIO (OR SULFINYL OR SULFONYL) DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1992-09-16 | — | — | EP | claimed |
| EP-0234980-A1 | 2-Benzimidazolylalkylthio (or sulfinyl or sulfonyl) derivatives, their preparation and their use as medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1987-09-02 | — | — | EP | claimed |