Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | CBFB | Q13951 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9665946 | 0.86 | NPC1 (0.43) | RAB9ANPC1POLBSMN1; SMN2METAP2 | |
| SCHEMBL9666973 | 0.84 | NPC1 (0.51) | RAB9ANPC1POLBSMN1; SMN2METAP2 | |
| SCHEMBL9667114 | 0.83 | IDH1 (0.38) | RAB9ANPC1TDP1POLBSMN1; SMN2 | |
| SCHEMBL9667203 | 0.82 | SMN1; SMN2 (0.46) | RAB9ANPC1TDP1POLBSMN1; SMN2 | |
| SCHEMBL9667049 | 0.82 | CBFB (0.43) | RAB9ANPC1CBFBLMNADRD4 | |
| SCHEMBL9668115 | 0.81 | METAP2 (0.50) | RAB9ANPC1TDP1POLBSMN1; SMN2 | |
| SCHEMBL9667018 | 0.81 | RIPK1 (0.46) | RAB9ANPC1TDP1POLBSMN1; SMN2 | |
| SCHEMBL9665723 | 0.80 | RAB9A (0.42) | RAB9ANPC1POLBSMN1; SMN2METAP1 | |
| SCHEMBL10772742 | 0.80 | PPARG (0.40) | RAB9ANPC1TDP1SMN1; SMN2KMT2A | |
| SCHEMBL9665954 | 0.79 | KMT2A (0.52) | RAB9ANPC1POLBSMN1; SMN2METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0234980-B1 | 2-BENZIMIDAZOLYLALKYLTHIO (OR SULFINYL OR SULFONYL) DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1992-09-16 | — | — | EP | claimed |
| EP-0234980-A1 | 2-Benzimidazolylalkylthio (or sulfinyl or sulfonyl) derivatives, their preparation and their use as medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 1987-09-02 | — | — | EP | claimed |