Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9668361 | 1.00 | HRH3 (0.50) | HRH3SIGMAR1MMP1MMP9MMP13 | |
| SCHEMBL9669926 | 0.86 | HTR2A (0.44) | DRD2DRD1DRD4DRD5DRD3 | |
| SCHEMBL9669966 | 0.78 | ALDH1A1 (0.47) | HRH3SIGMAR1ALDH1A1POLBTSHR | |
| SCHEMBL9208592 | 0.75 | HTR1A (0.50) | SIGMAR1 | |
| SCHEMBL9753177 | 0.75 | HRH3 (0.53) | HRH3ALDH1A1POLBTSHRFKBP1A | |
| SCHEMBL9753176 | 0.75 | HRH3 (0.53) | HRH3ALDH1A1POLBTSHRFKBP1A | |
| SCHEMBL7252710 | 0.74 | CARM1 (0.60) | HRH3SIGMAR1 | |
| SCHEMBL27370022 | 0.74 | HRH3 (0.58) | HRH3SIGMAR1 | |
| Bromide SCHEMBL7247424 | 0.73 | CARM1 (0.59) | HRH3SIGMAR1 | |
| SCHEMBL4806889 | 0.72 | HRH3 (0.66) | HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509005-A1 | DIPHENYLSULPHOXIMINE MUSCARINIC RECEPTOR ANTAGONISTS | Pfizer Limited (GB) | 1992-10-21 | — | — | EP | claimed |
| WO-1991010648-A1 | DIPHENYLSULPHOXIMINE MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER LIMITED (GB) | 1991-07-25 | — | — | WO | claimed |
| EP-0509005-A1 | DIPHENYLSULPHOXIMINE MUSCARINIC RECEPTOR ANTAGONISTS | Pfizer Limited (GB) | 1992-10-21 | — | — | EP | disclosed |
| WO-1991010648-A1 | DIPHENYLSULPHOXIMINE MUSCARINIC RECEPTOR ANTAGONISTS | PFIZER LIMITED (GB) | 1991-07-25 | — | — | WO | disclosed |