Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 8/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LSS | P48449 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CPN1 | P15169 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4143901 | 0.95 | HRH3 (0.42) | HRH3SIGMAR1ACP1NAAAHRH4 | |
| SCHEMBL9675335 | 0.88 | HRH3 (0.40) | HRH3ACP1NAAAHRH4KMT2A | |
| SCHEMBL9675697 | 0.83 | SIGMAR1 (0.59) | HRH3SIGMAR1ACP1NAAAHRH4 | |
| SCHEMBL19040837 | 0.81 | BCHE (0.40) | HRH3SIGMAR1NAAAHRH4KMT2A | |
| SCHEMBL14368874 | 0.80 | CYP1A2 (0.48) | HRH3ACP1NAAAHRH4KMT2A | |
| SCHEMBL14368866 | 0.80 | CYP1A2 (0.48) | HRH3ACP1NAAAHRH4KMT2A | |
| SCHEMBL902268 | 0.80 | CYP1A2 (0.48) | HRH3ACP1NAAAHRH4KMT2A | |
| SCHEMBL10324315 | 0.80 | SIGMAR1 (0.59) | SIGMAR1KMT2ALSSCYP1A2 | |
| SCHEMBL11170648 | 0.80 | HRH3 (0.51) | HRH3SIGMAR1ACP1NAAAHRH4 | |
| Hydrochloric Acid SCHEMBL4426631 | 0.79 | CYP1A2 (0.47) | HRH3ACP1NAAAHRH4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345629-B1 | CONDENSED DIAZEPINONES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |
| EP-0306698-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION, AND MEDICAMENTS CONTAINING THESE COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1992-03-25 | — | — | EP | disclosed |
| US-4931436-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1990-06-05 | — | — | US | disclosed |
| EP-0345629-A2 | Condensed diazepinones, process for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1989-12-13 | — | — | EP | disclosed |
| EP-0306698-A1 | Condensed diazepinones, processes for their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1989-03-15 | — | — | EP | disclosed |