Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 11/20 | 0.60 |
| ▸ | HTR1B | P28222 | 11/20 | 0.56 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9670304 | 0.92 | DRD3 (0.62) | HTR1DHTR1BDRD3HTR1ADRD2 | |
| SCHEMBL9668693 | 0.79 | HTR6 (0.58) | HTR1DHTR1BDRD3DRD2 | |
| SCHEMBL10972396 | 0.76 | HTR1D (0.65) | HTR1DHTR1BDRD3HTR1ADRD2 | |
| SCHEMBL8315256 | 0.75 | HTR1D (1.00) | HTR1DHTR1B | |
| SCHEMBL9668655 | 0.74 | DRD3 (0.40) | HTR1DHTR1BDRD3HTR1ADRD2 | |
| SCHEMBL9670486 | 0.72 | HTR1D (0.54) | HTR1DHTR1BDRD3HTR1ADRD2 | |
| SCHEMBL8312983 | 0.72 | HTR1B (1.00) | HTR1DHTR1BHTR1A | |
| SCHEMBL8893689 | 0.72 | HTR1D (0.62) | HTR1DHTR1BHTR1ADRD2 | |
| SCHEMBL8314594 | 0.71 | HTR1D (0.53) | HTR1DHTR1BDRD3HTR1ADRD2 | |
| SCHEMBL2599107 | 0.71 | HTR1A (0.76) | HTR1DHTR1BDRD3HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510068-A1 | NEW CENTRALLY ACTING 6,7,8,9-TETRAHYDRO-3H-BENZ(e)INDOLE HETEROCYCLICS | PHARMACIA & UPJOHN COMPANY (US) | 1992-10-28 | — | — | EP | disclosed |