Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 5/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | CLK2 | P49760 | 3/20 | 0.32 |
| ▸ | CLK3 | P49761 | 3/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9669186 | 0.88 | CDC7 (0.40) | CDK5CDK5R1CYP19A1CLK2DYRK1A | |
| SCHEMBL9667854 | 0.80 | ABL1 (0.34) | CDK5CDK5R1CYP19A1 | |
| SCHEMBL9669379 | 0.80 | PDE3B (0.45) | CDK5CDK5R1 | |
| SCHEMBL9669065 | 0.70 | CYP19A1 (0.52) | CDK5CDK5R1CYP19A1CLK2CLK3 | |
| SCHEMBL9669332 | 0.69 | CDK5 (0.41) | CDK5CDK5R1CYP19A1IDH1CLK2 | |
| SCHEMBL9667675 | 0.68 | KCNH2 (0.52) | — | |
| SCHEMBL9669307 | 0.67 | MAOB (0.43) | — | |
| SCHEMBL7355155 | 0.67 | KCNH2 (0.44) | — | |
| SCHEMBL22309145 | 0.67 | PDE3B (0.42) | — | |
| SCHEMBL4211464 | 0.67 | PDE3B (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223937-B1 | INDOLES SUBSTITUTED WITH HETEROCYCLES, INTERMEDIATES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1992-03-18 | — | — | EP | disclosed |
| US-4851406-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-25 | — | — | US | disclosed |