Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 6/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.41 |
| ▸ | PIM1 | P11309 | 3/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9669299 | 0.85 | CDC7 (0.40) | CDK5CDK5R1PIM1PIM3DYRK1A | |
| SCHEMBL9669332 | 0.82 | CDK5 (0.41) | CDK5CDK5R1PIM1PIM3DYRK1A | |
| SCHEMBL9668089 | 0.80 | CDK5 (0.38) | CDK5CDK5R1METAP2 | |
| SCHEMBL9670176 | 0.79 | PDGFRB (0.37) | CDK5CDK5R1PIM1PIM3DYRK1A | |
| SCHEMBL9667542 | 0.74 | GPR119 (0.40) | CDK5CDK5R1PIM1PIM2DYRK1A | |
| SCHEMBL9668467 | 0.74 | PDE3B (0.42) | CDK5CDK5R1MAPT | |
| SCHEMBL9670173 | 0.73 | MAOB (0.40) | CDK5CDK5R1 | |
| SCHEMBL9669416 | 0.72 | MMP13 (0.39) | — | |
| SCHEMBL31626826 | 0.71 | CYP19A1 (0.59) | CDK5CDK5R1PIM1GSK3BMAPT | |
| SCHEMBL701368 | 0.71 | CYP19A1 (0.59) | CDK5CDK5R1PIM1GSK3BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223937-B1 | INDOLES SUBSTITUTED WITH HETEROCYCLES, INTERMEDIATES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1992-03-18 | — | — | EP | disclosed |
| US-4851406-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE | BOEHRINGER MANNHEIM GMBH (DE) | 1989-07-25 | — | — | US | disclosed |
| EP-0223937-A1 | Indoles substituted with heterocycles, intermediates, process for their preparation and medicaments | Roche Diagnostics GmbH (DE) | 1987-06-03 | — | — | EP | disclosed |