Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 4/20 | 0.56 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 9/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.44 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.44 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.44 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.44 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.43 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.43 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9669718 | 0.88 | PDE7A (0.54) | PDE7APDE7BMAPTGAATDP1 | |
| SCHEMBL11709219 | 0.80 | MAPT (0.69) | PDE7APDE7BMAPTGAAMEN1 | |
| SCHEMBL2018745 | 0.80 | PDE7A (0.62) | PDE7APDE7BMAPTGAAMEN1 | |
| SCHEMBL9575765 | 0.77 | PDE7A (0.59) | PDE7APDE7BMAPTGAAMEN1 | |
| SCHEMBL9669410 | 0.77 | ALDH1A1 (0.49) | MAPTMEN1KMT2ATDP1HTT | |
| SCHEMBL810289 | 0.75 | PDE7A (0.68) | PDE7APDE7BMAPTGAAMEN1 | |
| SCHEMBL19048971 | 0.74 | PDE7A (0.71) | PDE7APDE7BMAPTGAAMEN1 | |
| SCHEMBL10368123 | 0.74 | MAPT (0.55) | PDE7APDE7BMAPTGAAMEN1 | |
| SCHEMBL1713219 | 0.74 | PDE7A (0.65) | PDE7APDE7BMAPTGAAMEN1 | |
| SCHEMBL30338244 | 0.74 | PDE7A (0.65) | PDE7APDE7BMAPTGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0163551-B1 | PHENOTHIAZINE COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-08-12 | — | — | EP | disclosed |
| US-4705854-A | ANTIALLERGENS, ANTIHISTAMINES | BURROUGHS WELLCOME CO. (US) | 1987-11-10 | — | — | US | disclosed |
| EP-0163551-A1 | Phenothiazine compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-12-04 | — | — | EP | disclosed |