Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9669803 | 0.93 | KMT2A (0.46) | KMT2AMEN1TRPV1MAPTHTT | |
| SCHEMBL8532689 | 0.88 | GPR84 (0.49) | KMT2AMEN1TRPV1MAPTGPR84 | |
| SCHEMBL8533040 | 0.84 | GPR84 (0.46) | KMT2AMEN1TRPV1MAPTHTT | |
| SCHEMBL8533902 | 0.84 | GPR84 (0.46) | KMT2AMEN1TRPV1MAPTHTT | |
| SCHEMBL9669804 | 0.84 | TDP1 (0.48) | KMT2AMEN1TRPV1LMNAGPR84 | |
| SCHEMBL8532302 | 0.83 | GPR84 (0.45) | KMT2AMEN1TRPV1MAPTGPR84 | |
| SCHEMBL9669701 | 0.83 | GPR84 (0.57) | KMT2AMEN1TRPV1MAPTHTT | |
| SCHEMBL8533704 | 0.83 | TRPV1 (0.54) | KMT2AMEN1TRPV1MAPTGPR84 | |
| SCHEMBL3671157 | 0.81 | GPR84 (0.42) | KMT2AMEN1TRPV1MAPTGPR84 | |
| SCHEMBL9372304 | 0.79 | ALDH1A1 (0.42) | KMT2AMEN1TRPV1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220066-B1 | CARBOXAMIDE DERIVATIVES | ICI AMERICAS INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| US-5049679-A | Leukotriene antagonists | ICI AMERICAS INC. (US) | 1991-09-17 | — | — | US | disclosed |
| US-5049576-A | Leukotriene antagonists | ICI AMERICAS INC. (US) | 1991-09-17 | — | — | US | disclosed |
| US-4918094-A | Carboxamide derivatives of indoles and leucotriene antagonizing use thereof | ICI AMERICAS INC. (US) | 1990-04-17 | — | — | US | disclosed |