Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31621465 | 1.00 | TDP1 (0.59) | TDP1ALDH1A1L3MBTL1LMNAKDM4E | |
| SCHEMBL6027390 | 0.83 | TDP1 (0.60) | TDP1ALDH1A1L3MBTL1LMNAKDM4E | |
| SCHEMBL2731836 | 0.82 | TDP1 (0.62) | TDP1ALDH1A1L3MBTL1LMNAKDM4E | |
| SCHEMBL9670265 | 0.80 | KDM4E (0.60) | ALDH1A1L3MBTL1LMNAKDM4EMEN1 | |
| SCHEMBL10916592 | 0.78 | RAB9A (0.67) | TDP1ALDH1A1L3MBTL1LMNAKDM4E | |
| SCHEMBL14010912 | 0.78 | ALDH1A1 (0.66) | TDP1ALDH1A1L3MBTL1LMNAKDM4E | |
| SCHEMBL11569355 | 0.78 | LMNA (0.60) | TDP1ALDH1A1L3MBTL1LMNAKDM4E | |
| SCHEMBL1520040 | 0.77 | SIRT2 (0.45) | TDP1ALDH1A1L3MBTL1LMNAKDM4E | |
| SCHEMBL24340312 | 0.77 | ALDH1A1 (0.51) | TDP1ALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL9374216 | 0.76 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1LMNAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0515535-A1 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO. INC. (US) | 1992-12-02 | — | — | EP | disclosed |
| WO-1991012001-A1 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO., INC. (US) | 1991-08-22 | — | — | WO | disclosed |
| US-4652558-A | FUNGICIDES, INSECTICIDES | CHEVRON RESEARCH COMPANY (US) | 1987-03-24 | — | — | US | disclosed |
| US-4605657-A | 4-quinazalone fungicides | CHEVRON RESEARCH COMPANY (US) | 1986-08-12 | — | — | US | disclosed |
| US-4039508-A | CROSSLINKED, POLYETHYLENE | INTERNATIONAL TELEPHONE AND TELEGRAPH CORPORATION (US) | 1977-08-02 | — | — | US | disclosed |