Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 6/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12862549 | 0.83 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2NPSR1TSHRHSD17B10 | |
| SCHEMBL9670265 | 0.83 | KDM4E (0.60) | ALDH1A1SMN1; SMN2TSHRHSD17B10L3MBTL1 | |
| SCHEMBL24340312 | 0.80 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2TSHRHSD17B10TDP1 | |
| SCHEMBL14010912 | 0.78 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2TSHRHSD17B10TDP1 | |
| SCHEMBL10739963 | 0.78 | ALDH1A1 (0.60) | ALDH1A1SMN1; SMN2TSHRTDP1L3MBTL1 | |
| SCHEMBL12565557 | 0.78 | LMNA (0.56) | ALDH1A1SMN1; SMN2NPSR1TSHRTDP1 | |
| SCHEMBL9724531 | 0.76 | TDP1 (0.59) | ALDH1A1SMN1; SMN2HSD17B10TDP1L3MBTL1 | |
| SCHEMBL9671285 | 0.76 | MEN1 (0.69) | ALDH1A1SMN1; SMN2HSD17B10MEN1KMT2A | |
| SCHEMBL31621465 | 0.76 | TDP1 (0.59) | ALDH1A1SMN1; SMN2HSD17B10TDP1L3MBTL1 | |
| SCHEMBL9602807 | 0.75 | TLR7 (0.43) | ALDH1A1SMN1; SMN2NPSR1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276825-B1 | 4 (3H)-QUINAZOLINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1992-09-09 | — | — | EP | disclosed |
| EP-0276826-B1 | 2-ALKYLSULFINYL-4 (3H)-QUINAZOLINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1991-12-27 | — | — | EP | disclosed |
| US-5008266-A | Antiulcer agent | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1991-04-16 | — | — | US | disclosed |
| US-4861780-A | 4(3H)-quinazolinone derivatives and pharmaceutical compositions | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1989-08-29 | — | — | US | disclosed |
| US-4833144-A | ANTIULCER AGENTS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1989-05-23 | — | — | US | disclosed |
| EP-0276825-A1 | 4 (3H)-Quinazolinone derivatives, processes for their preparation and pharmaceutical compositions | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1988-08-03 | — | — | EP | disclosed |
| EP-0276826-A1 | 2-Alkylsulfinyl-4 (3H)-quinazolinone derivatives, processes for their preparation and pharmaceutical compositions | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1988-08-03 | — | — | EP | disclosed |