Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.53 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.53 |
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | APEX1 | P27695 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9671520 | 0.93 | ALDH1A1 (0.52) | ALDH1A1PKMCHRM2CHRM1CHRM3 | |
| Iodide SCHEMBL9677423 | 0.92 | ALDH1A1 (0.56) | ALDH1A1PKMCHRM2CHRM1CHRM3 | |
| Iodide SCHEMBL9670702 | 0.90 | ALDH1A1 (0.54) | ALDH1A1PKMCHRM2CHRM1CHRM3 | |
| Iodide SCHEMBL9671924 | 0.90 | ALDH1A1 (0.54) | ALDH1A1PKMCHRM2CHRM1CHRM3 | |
| Iodide SCHEMBL28875132 | 0.88 | CHRM2 (0.58) | ALDH1A1PKMCHRM2CHRM1CHRM3 | |
| SCHEMBL18053293 | 0.85 | CHRM2 (0.55) | ALDH1A1CHRM2CHRM1CHRM3MEN1 | |
| Iodide SCHEMBL9670708 | 0.84 | CHRM2 (0.59) | ALDH1A1PKMCHRM2CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL28353709 | 0.83 | KDM4E (0.54) | ALDH1A1CHRM2CHRM1CHRM3MEN1 | |
| Iodide SCHEMBL9670517 | 0.81 | CHRM2 (0.51) | ALDH1A1CHRM2CHRM1CHRM3KDM4E | |
| SCHEMBL11320864 | 0.80 | IGF1R (0.48) | ALDH1A1PKMCHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5093370-A | Useful prior to insertion of tracheotomy tube or discission | TOBISHI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1992-03-03 | — | — | US | disclosed |