Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.51 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9672333 | 0.98 | SIGMAR1 (0.52) | CHRM2CHRM1CHRM3L3MBTL1MAOA | |
| SCHEMBL11134605 | 0.98 | MAOA (0.52) | CHRM2CHRM1CHRM3L3MBTL1MAOA | |
| Hydrochloric Acid SCHEMBL28728354 | 0.96 | KDM4E (0.52) | CHRM2CHRM1CHRM3L3MBTL1MAOA | |
| SCHEMBL9670784 | 0.96 | SIGMAR1 (0.53) | L3MBTL1MAOASIGMAR1 | |
| Hydrochloric Acid SCHEMBL10607355 | 0.94 | SIGMAR1 (0.52) | L3MBTL1MAOASIGMAR1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL10426027 | 0.94 | SIGMAR1 (0.52) | L3MBTL1MAOASIGMAR1KDM4EALDH1A1 | |
| Bromide SCHEMBL29198641 | 0.94 | SIGMAR1 (0.52) | L3MBTL1MAOASIGMAR1KDM4E | |
| Hydrochloric Acid SCHEMBL11703699 | 0.94 | SIGMAR1 (0.52) | L3MBTL1MAOASIGMAR1KDM4EALDH1A1 | |
| Iodide SCHEMBL28875132 | 0.93 | CHRM2 (0.58) | CHRM2CHRM1CHRM3L3MBTL1MAOA | |
| SCHEMBL18053293 | 0.91 | CHRM2 (0.55) | CHRM2CHRM1CHRM3L3MBTL1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5093370-A | Useful prior to insertion of tracheotomy tube or discission | TOBISHI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1992-03-03 | — | — | US | disclosed |