Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 6/20 | 0.41 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | PPOX | P50336 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | S100A4 | P26447 | 1/20 | 0.31 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9672482 | 0.84 | AKR1B1 (0.41) | AKR1B1AKR1A1 | |
| SCHEMBL10931287 | 0.81 | AKR1B1 (0.38) | AKR1B1AKR1A1CES1PPOXCMA1 | |
| SCHEMBL9673138 | 0.67 | AKR1B1 (0.50) | AKR1B1AKR1A1 | |
| SCHEMBL9672313 | 0.65 | AKR1B1 (0.38) | AKR1B1AKR1A1 | |
| SCHEMBL9673448 | 0.62 | ITGA4 (0.44) | AKR1B1AKR1A1PDK2S100A4 | |
| SCHEMBL10832012 | 0.60 | MAP3K14 (0.41) | AKR1B1AKR1A1 | |
| SCHEMBL9674044 | 0.59 | AKR1B1 (0.38) | AKR1B1AKR1A1CES1PPOXCMA1 | |
| SCHEMBL9672798 | 0.59 | AKR1B1 (0.71) | AKR1B1AKR1A1PPOX | |
| SCHEMBL11001789 | 0.59 | AKR1B1 (1.00) | AKR1B1AKR1A1PPOX | |
| SCHEMBL9672186 | 0.59 | AKR1B1 (0.56) | AKR1B1AKR1A1PPOXCMA1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0137333-B1 | SPIRO-TRICYCLICAROMATIC SUCCINIMIDE DERIVATIVES AS INHIBITORS OF ALDOSE REDUCTASE | ALCON LABORATORIES, INC. (US) | 1992-12-30 | — | — | EP | disclosed |
| US-5153211-A | Enzyme inhibitors | ALCON LABORATORIES, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| US-5070100-A | COMPLICATIONS OF DIABETES | ALCON LABORATORIES, INC. (US) | 1991-12-03 | — | — | US | disclosed |
| US-4864028-A | ANTIDIABETIC AGENTS | ALCON LABORATORIES, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| US-4717725-A | SPIROCYCLIC AROMATIC IMIDES | ALCON LABORATORIES, INC. (US) | 1988-01-05 | — | — | US | disclosed |
| US-4537892-A | ANTIDIABETIC AGENTS | ALCON LABORATORIES, INC. (US) | 1985-08-27 | — | — | US | disclosed |