Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.56 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.38 |
| ▸ | PPOX | P50336 | 1/20 | 0.37 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10345954 | 0.73 | AKR1B1 (0.55) | AKR1B1AKR1A1CCNB2CDK1CCNB1 | |
| SCHEMBL8804611 | 0.72 | AKR1B1 (1.00) | AKR1B1AKR1A1 | |
| SCHEMBL9674044 | 0.72 | AKR1B1 (0.38) | AKR1B1AKR1A1PPOXCMA1AHR | |
| SCHEMBL10931287 | 0.72 | AKR1B1 (0.38) | AKR1B1AKR1A1PPOXCMA1AHR | |
| SCHEMBL9672798 | 0.72 | AKR1B1 (0.71) | AKR1B1AKR1A1PPOX | |
| SCHEMBL2483457 | 0.71 | AKR1B1 (0.56) | AKR1B1CMA1AHR | |
| SCHEMBL10930896 | 0.71 | AKR1B1 (0.56) | AKR1B1AKR1A1CRBN | |
| SCHEMBL20850099 | 0.69 | CASP3 (0.37) | AKR1B1AKR1A1PPOX | |
| SCHEMBL2484250 | 0.68 | AKR1B1 (0.52) | AKR1B1CMA1AHR | |
| SCHEMBL9673456 | 0.67 | AKR1B1 (0.57) | AKR1B1AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0137333-B1 | SPIRO-TRICYCLICAROMATIC SUCCINIMIDE DERIVATIVES AS INHIBITORS OF ALDOSE REDUCTASE | ALCON LABORATORIES, INC. (US) | 1992-12-30 | — | — | EP | disclosed |
| US-5153211-A | Enzyme inhibitors | ALCON LABORATORIES, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| US-5070100-A | COMPLICATIONS OF DIABETES | ALCON LABORATORIES, INC. (US) | 1991-12-03 | — | — | US | disclosed |
| US-4864028-A | ANTIDIABETIC AGENTS | ALCON LABORATORIES, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| US-4537892-A | ANTIDIABETIC AGENTS | ALCON LABORATORIES, INC. (US) | 1985-08-27 | — | — | US | disclosed |