Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 11/20 | 0.41 |
| ▸ | AKR1A1 | P14550 | 7/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9673138 | 0.85 | AKR1B1 (0.50) | AKR1B1AKR1A1CYP1A2MAPTCYP2C19 | |
| SCHEMBL9671764 | 0.84 | AKR1B1 (0.41) | AKR1B1AKR1A1 | |
| SCHEMBL9672313 | 0.81 | AKR1B1 (0.38) | AKR1B1AKR1A1CYP1A2MAPTCYP2C19 | |
| SCHEMBL9674196 | 0.75 | AKR1A1 (0.40) | AKR1B1AKR1A1CYP1A2MAPTCYP2C19 | |
| SCHEMBL9672261 | 0.74 | AKR1A1 (0.40) | AKR1B1AKR1A1CYP1A2MAPTCYP2C19 | |
| SCHEMBL9673456 | 0.73 | AKR1B1 (0.57) | AKR1B1AKR1A1CYP1A2MAPTCYP2C19 | |
| SCHEMBL9672255 | 0.73 | AKR1A1 (0.71) | AKR1B1AKR1A1MAPT | |
| SCHEMBL9671932 | 0.73 | PDK2 (0.36) | AKR1B1AKR1A1CYP1A2MAPTCYP2C19 | |
| SCHEMBL10931287 | 0.65 | AKR1B1 (0.38) | AKR1B1AKR1A1 | |
| SCHEMBL9673448 | 0.62 | ITGA4 (0.44) | AKR1B1AKR1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0137333-B1 | SPIRO-TRICYCLICAROMATIC SUCCINIMIDE DERIVATIVES AS INHIBITORS OF ALDOSE REDUCTASE | ALCON LABORATORIES, INC. (US) | 1992-12-30 | — | — | EP | disclosed |
| US-5153211-A | Enzyme inhibitors | ALCON LABORATORIES, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| US-5070100-A | COMPLICATIONS OF DIABETES | ALCON LABORATORIES, INC. (US) | 1991-12-03 | — | — | US | disclosed |
| US-4864028-A | ANTIDIABETIC AGENTS | ALCON LABORATORIES, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| US-4537892-A | ANTIDIABETIC AGENTS | ALCON LABORATORIES, INC. (US) | 1985-08-27 | — | — | US | disclosed |