Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 9/20 | 0.43 |
| ▸ | AKR1A1 | P14550 | 7/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9811098 | 0.84 | AKR1B1 (0.58) | TDP1AKR1B1AKR1A1ITGA4TDP2 | |
| SCHEMBL9810966 | 0.83 | ITGA4 (0.65) | TDP1AKR1B1AKR1A1ITGA4TDP2 | |
| SCHEMBL9672105 | 0.81 | AKR1A1 (0.68) | AKR1B1AKR1A1ITGA4 | |
| SCHEMBL10907091 | 0.81 | AKR1B1 (0.68) | AKR1B1AKR1A1ITGA4 | |
| SCHEMBL9671558 | 0.81 | AKR1B1 (0.59) | AKR1B1AKR1A1ITGA4 | |
| SCHEMBL9671809 | 0.80 | ITGA4 (0.68) | TDP1MAPTAKR1B1AKR1A1ITGA4 | |
| SCHEMBL25063677 | 0.69 | AKR1A1 (0.43) | MAPTAKR1B1AKR1A1ITGA4 | |
| SCHEMBL25063575 | 0.67 | ITGA4 (0.58) | AKR1B1AKR1A1ITGA4TDP2 | |
| SCHEMBL8343435 | 0.66 | TDP1 (1.00) | TDP1MAPTL3MBTL1MAPK1TDP2 | |
| SCHEMBL9055622 | 0.66 | TDP1 (0.78) | TDP1MAPTL3MBTL1MAPK1TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0137333-B1 | SPIRO-TRICYCLICAROMATIC SUCCINIMIDE DERIVATIVES AS INHIBITORS OF ALDOSE REDUCTASE | ALCON LABORATORIES, INC. (US) | 1992-12-30 | — | — | EP | disclosed |
| US-5153211-A | Enzyme inhibitors | ALCON LABORATORIES, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| US-5070100-A | COMPLICATIONS OF DIABETES | ALCON LABORATORIES, INC. (US) | 1991-12-03 | — | — | US | disclosed |
| US-4864028-A | ANTIDIABETIC AGENTS | ALCON LABORATORIES, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| US-4717725-A | SPIROCYCLIC AROMATIC IMIDES | ALCON LABORATORIES, INC. (US) | 1988-01-05 | — | — | US | disclosed |
| US-4537892-A | ANTIDIABETIC AGENTS | ALCON LABORATORIES, INC. (US) | 1985-08-27 | — | — | US | disclosed |
| EP-0137333-A2 | Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase | ALCON LABORATORIES, INC. (US) | 1985-04-17 | — | — | EP | disclosed |