Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 12/20 | 0.58 |
| ▸ | AKR1A1 | P14550 | 10/20 | 0.58 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TDP2 | O95551 | 1/20 | 0.47 |
| ▸ | PTPRC | P08575 | 1/20 | 0.46 |
| ▸ | S100A4 | P26447 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9810966 | 0.93 | ITGA4 (0.65) | AKR1B1AKR1A1ITGA4CYP3A4TDP1 | |
| SCHEMBL9671858 | 0.84 | TDP1 (0.49) | AKR1B1AKR1A1ITGA4CYP3A4TDP1 | |
| SCHEMBL27233049 | 0.77 | ALDH1A1 (0.56) | AKR1B1ITGA4CYP3A4TDP1ALDH1A1 | |
| SCHEMBL9811003 | 0.73 | AKR1A1 (0.65) | AKR1B1AKR1A1ITGA4ALDH1A1 | |
| SCHEMBL22380780 | 0.73 | AKR1B1 (0.65) | AKR1B1AKR1A1ITGA4ALDH1A1 | |
| Imirestat SCHEMBL30924520 | 0.73 | AKR1A1 (1.00) | AKR1B1AKR1A1ITGA4 | |
| Imirestat SCHEMBL49034 | 0.73 | AKR1A1 (1.00) | AKR1B1AKR1A1ITGA4 | |
| SCHEMBL11001789 | 0.73 | AKR1B1 (1.00) | AKR1B1AKR1A1ITGA4 | |
| SCHEMBL12282222 | 0.72 | PTPRC (0.53) | CYP3A4TDP1TDP2PTPRCS100A4 | |
| SCHEMBL24193439 | 0.72 | MAPT (0.69) | AKR1B1ITGA4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0092385-B1 | HYDANTOIN DERIVATIVES FOR USE IN INHIBITING ALDOSE REDUCTASE ACTIVITY, COMPOSITIONS THEREFOR AND PROCESS FOR PREPARING SPIRO-FLUOREN COMPOUNDS | ALCON LABORATORIES, INC. (US) | 1991-06-12 | — | — | EP | disclosed |
| US-4540700-A | Treatment of diabetic complications with certain spiro-imidazolidine-diones | ALCON LABORATORIES, INC. (US) | 1985-09-10 | — | — | US | disclosed |
| US-4436745-A | TETRACYCLIC SPIROHYDANTOINS | ALCON LABORATORIES, INC. (US) | 1984-03-13 | — | — | US | disclosed |
| WO-1983003543-A1 | METHOD OF INHIBITING ALDOSE REDUCTASE ACTIVITY, COMPOSITIONS THEREFOR AND PROCESS FOR PREPARING SPIRO-FLUOROFLUOREN AND SPIRO-DIFLUOROFLUOREN COMPOUNDS | ALCON LAB INC (US) | 1983-10-27 | — | — | WO | disclosed |