Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9674583 | 0.85 | HSD11B1 (0.39) | ALDH1A1AGTR1HPGDCYP1A2CYP3A4 | |
| SCHEMBL32689790 | 0.79 | PLAU (0.55) | — | |
| SCHEMBL10840357 | 0.74 | SMN1; SMN2 (0.47) | CYP3A4CYP2D6CYP2C19CYP2C9ALOX15 | |
| SCHEMBL9672814 | 0.73 | SLC6A2 (0.41) | CYP3A4CYP2D6CYP2C9SMN1; SMN2 | |
| SCHEMBL12467412 | 0.70 | CYP2C9 (0.43) | HPGDCYP2C9SMN1; SMN2PDE4D | |
| SCHEMBL9672475 | 0.70 | HSD11B1 (0.42) | ALDH1A1AGTR1HPGDCYP1A2CYP3A4 | |
| SCHEMBL3952392 | 0.70 | HPGD (0.62) | ALDH1A1AGTR1HPGDKDM4E | |
| SCHEMBL5783160 | 0.69 | CYP2C9 (0.42) | ALDH1A1CYP2C9KDM4ENPC1RAB9A | |
| SCHEMBL30364398 | 0.69 | LMNA (0.43) | ALDH1A1HPGDCYP2C9NPC1RAB9A | |
| SCHEMBL28942777 | 0.69 | LMNA (0.43) | ALDH1A1HPGDCYP2C9NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0178633-B1 | 2-phenylpyrano[2,3-b]pyridines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-01-08 | — | — | EP | disclosed |
| US-4588733-A | 2-phenylpyrano[2,3-b]pyridines and their use in inhibiting viruses | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-05-13 | — | — | US | disclosed |
| EP-0178633-A2 | 2-phenylpyrano[2,3-b]pyridines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-04-23 | — | — | EP | disclosed |