Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4190526 | 0.97 | TYR (0.44) | TYRHTTHPGDIDO1MGLL | |
| Bromide SCHEMBL10807840 | 0.94 | TYR (0.42) | TYRHTTHPGDIDO1MGLL | |
| Hydrochloric Acid SCHEMBL6675199 | 0.91 | ACHE (0.39) | TYRHTTHPGDIDO1NOTUM | |
| SCHEMBL424555 | 0.87 | RAB9A (0.39) | TYRHTTHPGDALDH1A1CYP2C9 | |
| SCHEMBL92099 | 0.87 | ACHE (0.40) | TYRHTTHPGDIDO1SMN1; SMN2 | |
| SCHEMBL35211532 | 0.87 | TYR (0.38) | TYRHTTHPGDIDO1MGLL | |
| SCHEMBL10726396 | 0.87 | TYR (0.38) | TYRHTTHPGDIDO1MGLL | |
| Bromide SCHEMBL30579933 | 0.85 | ACHE (0.39) | TYRHTTHPGDIDO1SMN1; SMN2 | |
| SCHEMBL7896687 | 0.82 | MCOLN3 (0.45) | TYRMGLLALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4196657 | 0.82 | CYP2D6 (0.41) | TYRHPGDALDH1A1LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110003123-A1 | SENSITIZER/INITIATOR COMBINATION FOR NEGATIVE-WORKING THERMAL-SENSITIVE COMPOSITIONS USABLE FOR LITHOGRAPHIC PLATES | KODAK GRAPHIC COMMUNICATIONS, GMBH (DE) | 2011-01-06 | — | — | US | disclosed |