Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.49 |
| ▸ | IDH2 | P48735 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CASR | P41180 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3459439 | 0.85 | KMT2A (0.51) | LMNAGAAKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL967264 | 0.82 | GAA (0.52) | LMNAGAAKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL967254 | 0.78 | SMN1; SMN2 (0.63) | LMNAGAAKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL19745233 | 0.77 | RAB9A (0.64) | LMNAGAAKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5141402 | 0.77 | ALDH1A1 (0.50) | LMNAGAAKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5561958 | 0.76 | SMN1; SMN2 (0.63) | LMNAGAAKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL31093984 | 0.76 | SMN1; SMN2 (0.63) | LMNAGAAKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5133570 | 0.75 | SMN1; SMN2 (0.62) | LMNAGAAKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL963688 | 0.75 | SMN1; SMN2 (0.62) | LMNAGAAKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL965697 | 0.74 | TP53 (0.62) | LMNAGAAKMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110021525-A1 | P70S6 Kinase Modulators and Method of Use | EXELIXIS, INC. (US) | 2011-01-27 | — | — | US | disclosed |
| US-7816353-B2 | P70S6 kinase modulators and method of use | EXELIXIS, INC. (US) | 2010-10-19 | — | — | US | disclosed |
| US-20070208020-A1 | P70S6 Kinase Modulators And Method Of Use | EXELIXIS, INC. | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021525-A1 | P70S6 Kinase Modulators and Method of Use | EEF2K, RPS6KA3, MTOR | LMNA 3817/4885GAA 950/4885KMT2A 3420/4885 |
| US-20070208020-A1 | P70S6 Kinase Modulators And Method Of Use | EEF2K, RPS6KA3, MTOR | LMNA 3817/4885GAA 950/4885KMT2A 3420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.