Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.48 |
| ▸ | RECQL | P46063 | 5/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | BLM | P54132 | 4/20 | 0.48 |
| ▸ | USP2 | O75604 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | APEX1 | P27695 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | RGS12 | O14924 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.48 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9673110 | 0.82 | KDM4E (0.46) | KDM4EHSD17B10RECQLHIF1ATDP1 | |
| SCHEMBL28157600 | 0.79 | KDM4E (0.44) | KDM4EHSD17B10RECQLHIF1ATDP1 | |
| SCHEMBL11800568 | 0.79 | KDM4E (0.52) | KDM4EHSD17B10RECQLHIF1ATDP1 | |
| SCHEMBL11793624 | 0.78 | SMN1; SMN2 (0.55) | KDM4EHSD17B10RECQLHIF1ATDP1 | |
| SCHEMBL5663915 | 0.77 | ESR1 (0.41) | KDM4EHSD17B10RECQLHIF1AHPGD | |
| SCHEMBL4351797 | 0.76 | ALDH1A1 (0.45) | TDP1POLBALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL10441674 | 0.74 | HDAC3 (0.40) | HSD17B10MEN1APEX1KMT2ASMN1; SMN2 | |
| SCHEMBL31572011 | 0.74 | TDP1 (0.55) | KDM4EHSD17B10RECQLHIF1ATDP1 | |
| SCHEMBL6346993 | 0.73 | SMN1; SMN2 (0.46) | KDM4EHSD17B10RECQLHIF1ATDP1 | |
| SCHEMBL8502015 | 0.73 | KDM4E (0.46) | KDM4EHSD17B10RECQLHIF1ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0251143-B1 | 2-Oxo-1-[[(Substituted Sulfonyl)Amino]-Carbonyl]Azetidines | Bristol-Myers Squibb GmbH (DE) | 1992-08-26 | — | — | EP | disclosed |
| US-4801705-A | 2-oxo-1-(((substituted sulfonyl)amino)-carbonyl)azetidines | E. R. SQUIBB & SONS, INC. (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0251143-A1 | 2-Oxo-1-[[(Substituted Sulfonyl)Amino]-Carbonyl]Azetidines | Bristol-Myers Squibb GmbH (DE) | 1988-01-07 | — | — | EP | disclosed |