Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31526173 | 0.81 | CYP11B1 (0.53) | CYP11B1CYP11B2AKR1B1ALOX15ALDH1A1 | |
| SCHEMBL27862904 | 0.74 | ALDH1A1 (0.42) | CYP11B1CYP11B2ALOX15ALDH1A1KDM4E | |
| SCHEMBL4587159 | 0.71 | CYP11B1 (0.42) | CYP11B1CYP11B2ALOX15ALDH1A1KDM4E | |
| SCHEMBL28020956 | 0.69 | CYP11B1 (0.41) | CYP11B1CYP11B2AKR1B1ALOX15ALDH1A1 | |
| SCHEMBL28013350 | 0.69 | CYP11B1 (0.41) | CYP11B1CYP11B2AKR1B1ALOX15ALDH1A1 | |
| SCHEMBL27304439 | 0.69 | CYP11B1 (0.41) | CYP11B1CYP11B2AKR1B1ALOX15ALDH1A1 | |
| SCHEMBL10166456 | 0.69 | CYP11B1 (0.46) | CYP11B1CYP11B2ALOX15ALDH1A1KDM4E | |
| SCHEMBL6739617 | 0.69 | ALDH1A1 (0.42) | CYP11B1CYP11B2ALOX15ALDH1A1KDM4E | |
| SCHEMBL28957794 | 0.69 | CYP11B1 (0.41) | CYP11B1CYP11B2AKR1B1ALOX15ALDH1A1 | |
| SCHEMBL20079998 | 0.67 | FFAR4 (0.45) | CYP11B1CYP11B2AKR1B1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0222576-B1 | HETEROCYCLIC OXOPHTHALAZINYL ACETIC ACIDS | PFIZER INC. (US) | 1992-03-18 | — | — | EP | disclosed |
| CN-1009831-B | PROCESS FOR PREPARING HETEROCYCLE-OXO-2,3-DIAZANAPHTHYL-ACETIC ACID | PFIZER (US) | 1990-10-03 | — | — | CN | disclosed |