Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL967565 | 0.77 | CYP2A6 (0.40) | CYP2A6CTSLCTSSCTSKTACR1 | |
| SCHEMBL967564 | 0.77 | CYP2A6 (0.40) | CYP2A6CTSLCTSSCTSKTACR1 | |
| SCHEMBL5116926 | 0.72 | LOXL2 (0.38) | — | |
| SCHEMBL4415047 | 0.70 | CYP2A6 (0.35) | CYP2A6CHRNA7 | |
| SCHEMBL827106 | 0.64 | CYP2A6 (0.60) | CYP2A6CTSLCTSSCTSKSMN1; SMN2 | |
| SCHEMBL22872303 | 0.63 | CTSL (0.54) | CYP2A6CTSLCTSSCTSKTACR1 | |
| SCHEMBL17413363 | 0.62 | CYP2A6 (0.59) | CYP2A6SMN1; SMN2ALDH1A1IDO1TAAR1 | |
| SCHEMBL21889905 | 0.62 | CYP2A6 (0.56) | CYP2A6CTSLCTSSCTSKSMN1; SMN2 | |
| SCHEMBL14478280 | 0.62 | CYP2A6 (0.59) | CYP2A6SMN1; SMN2ALDH1A1IDO1TAAR1 | |
| SCHEMBL5540711 | 0.62 | CYP2A6 (0.56) | CYP2A6CTSLCTSSCTSKSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872045-B2 | Treating ocular hypertension, glaucoma, by administering prostaglandin derivatives such as {3-[(1R,2S,3R)-3-Hydroxy-2-((S)-(E)-3-(hydroxy)-5-(naphthyl)pent-1-enyl)-5-oxocyclopentylsulfanyl]propylsulfanyl}acetic acid methyl ester | ALLERGAN, INC. (US) | 2011-01-18 | — | — | US | disclosed |
| EP-1395263-B1 | 3, 7 OR 3 AND 7 THIA OR OXA PROSTANOIC ACID DERIVATIVES AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE | ALLERGAN INC (US) | 2009-12-30 | — | — | EP | disclosed |
| US-7473704-B2 | Cyclohexyl prostaglandin analogs as EP4-receptor agonists | ALLERGAN, INC. (US) | 2009-01-06 | — | — | US | disclosed |
| US-7429615-B2 | Cyclohexyl prostaglandin analogs as EP4-receptor agonists | ALLERGAN, INC. (US) | 2008-09-30 | — | — | US | disclosed |
| US-20060247215-A1 | Cyclohexyl prostaglandin analogs as rp4-receptor agonists | OLD DAVID W | 2006-11-02 | — | — | US | disclosed |
| US-7015243-B2 | Cyclohexyl prostaglandin analogs as EP4-receptor agonists | ALLERGAN, INC. (US) | 2006-03-21 | — | — | US | disclosed |
| US-20060030606-A1 | Cyclohexyl prostaglandin analogs as EP4-receptor agonists | ALLERGAN, INC. | 2006-02-09 | — | — | US | disclosed |
| US-6956057-B2 | EP4 agonists as agents for lowering intraocular pressure | ALLERGAN, INC. (US) | 2005-10-18 | — | — | US | disclosed |
| US-20050222094-A1 | Treatment of inflammatory bowel disease | ALLERGAN, INC. | 2005-10-06 | — | — | US | disclosed |
| US-20050209194-A1 | Combination therapy for glaucoma treatment | ALLERGAN, INC. | 2005-09-22 | — | — | US | disclosed |
| US-20050049227-A1 | Cyclohexyl prostaglandin analogs as EP4-receptor agonists | ALLERGAN, INC. | 2005-03-03 | — | — | US | disclosed |
| US-20040102499-A1 | EP4 agonists as agents for lowering intraocular pressure | ALLERGAN, INC. | 2004-05-27 | — | — | US | disclosed |
| US-6538018-B1 | Method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound | ALLERGAN, INC. | 2003-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247215-A1 | Cyclohexyl prostaglandin analogs as rp4-receptor agonists | PTGER4, PTGER1, PTGER3 | CYP2A6 645/4885CTSL 2487/4885CTSS 3700/4885 |
| US-20050222094-A1 | Treatment of inflammatory bowel disease | SLC10A2, NR1H4, FABP2 | CYP2A6 1292/4885CTSL 2577/4885CTSS 2662/4885 |
| US-20060030606-A1 | Cyclohexyl prostaglandin analogs as EP4-receptor agonists | PTGER4, PTGER1, PTGIR | CYP2A6 532/4885CTSL 2496/4885CTSS 3460/4885 |
| US-20050049227-A1 | Cyclohexyl prostaglandin analogs as EP4-receptor agonists | PTGER4, PTGER1, PTGIR | CYP2A6 532/4885CTSL 2496/4885CTSS 3460/4885 |
| US-20050209194-A1 | Combination therapy for glaucoma treatment | RHOXF2, EDNRB, PDE6D | CYP2A6 2417/4885CTSL 3929/4885CTSS 3764/4885 |
| US-20040102499-A1 | EP4 agonists as agents for lowering intraocular pressure | PTGER4, PTGIR, PTGER1 | CYP2A6 1383/4885CTSL 3496/4885CTSS 4338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.