Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29081736 | 0.86 | HDAC6 (0.46) | LOXL2DYRK1ATRPV1AKR1B1GAA | |
| SCHEMBL29184144 | 0.86 | RAB9A (0.47) | DYRK1AAKR1B1GAAPPARANPC1 | |
| SCHEMBL201370 | 0.84 | DYRK1A (0.46) | LOXL2DYRK1ATRPV1AKR1B1GAA | |
| SCHEMBL31003151 | 0.82 | NPC1 (0.63) | LOXL2DYRK1ATRPV1AKR1B1GAA | |
| SCHEMBL2947099 | 0.82 | NPC1 (0.63) | LOXL2DYRK1ATRPV1AKR1B1GAA | |
| SCHEMBL3247063 | 0.82 | LOXL2 (0.65) | LOXL2DYRK1ATRPV1AKR1B1GAA | |
| Hydrochloric Acid SCHEMBL29456890 | 0.81 | LOXL2 (0.63) | LOXL2DYRK1ATRPV1AKR1B1GAA | |
| SCHEMBL27281641 | 0.81 | DYRK1A (0.44) | LOXL2DYRK1ATRPV1AKR1B1GAA | |
| Hydrochloric Acid SCHEMBL20511957 | 0.81 | LOXL2 (0.63) | LOXL2DYRK1ATRPV1AKR1B1GAA | |
| Iodide SCHEMBL31511840 | 0.81 | LOXL2 (0.63) | LOXL2DYRK1ATRPV1AKR1B1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0222576-B1 | HETEROCYCLIC OXOPHTHALAZINYL ACETIC ACIDS | PFIZER INC. (US) | 1992-03-18 | — | — | EP | disclosed |
| CN-1009831-B | PROCESS FOR PREPARING HETEROCYCLE-OXO-2,3-DIAZANAPHTHYL-ACETIC ACID | PFIZER (US) | 1990-10-03 | — | — | CN | disclosed |
| US-4748280-A | Certain chlorination process for preparing 2-chloro-1,1,1-(C1 -C6) | PFIZER INC. (US) | 1988-05-31 | — | — | US | disclosed |
| US-4723010-A | Process for preparing chloromethyl thiazoles or oxazoles, and intermediates for use therein | PFIZER INC. (US) | 1988-02-02 | — | — | US | disclosed |
| CN-86108308-A | Heterocycle oxo-2 guanidine-acetic acid | — | 1987-07-15 | — | — | CN | disclosed |
| EP-0222576-A2 | Heterocyclic oxophthalazinyl acetic acids | PFIZER INC. (US) | 1987-05-20 | — | — | EP | disclosed |