Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9583278 | 0.80 | SRD5A1 (0.41) | AHRALDH1A1SMN1; SMN2KDM4EGAA | |
| SCHEMBL9582306 | 0.80 | SRD5A1 (0.41) | TRPM8AHRKDM4ECYP2C19CYP2C9 | |
| SCHEMBL9582612 | 0.80 | SRD5A1 (0.42) | TRPM8AHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL9582747 | 0.80 | DRD2 (0.49) | — | |
| SCHEMBL9582520 | 0.80 | FKBP1A (0.39) | TRPM8AHROPRK1CYP2C19CYP2C9 | |
| SCHEMBL9582674 | 0.80 | HTR2A (0.40) | TRPM8AHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL9583579 | 0.80 | HTR2A (0.40) | AHRALDH1A1SMN1; SMN2KDM4EOPRK1 | |
| SCHEMBL29961061 | 0.79 | ALDH1A1 (0.56) | TRPM8AHRCHRNA7ALDH1A1SMN1; SMN2 | |
| SCHEMBL27625794 | 0.79 | ALDH1A1 (0.56) | TRPM8AHRCHRNA7ALDH1A1SMN1; SMN2 | |
| SCHEMBL27082921 | 0.79 | ALDH1A1 (0.56) | TRPM8AHRCHRNA7ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0505183-A2 | Process for the preparation of (8aS,12aS,13aS)-decahydroisoquino[2,1-g][1,6]-naphthyridin-8-one derivatives | SYNTEX (U.S.A.) INC. (US) | 1992-09-23 | — | — | EP | disclosed |