Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 4/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 4/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9844402 | 0.91 | GRM2 (0.44) | GRM2SIGMAR1MAPK1MCHR1HTR2A | |
| SCHEMBL9678769 | 0.88 | GRM2 (0.55) | GRM2SIGMAR1ATM | |
| SCHEMBL9678414 | 0.88 | SIGMAR1 (0.55) | GRM2SIGMAR1 | |
| SCHEMBL9678999 | 0.86 | GRM2 (0.43) | GRM2SIGMAR1SMN1; SMN2 | |
| SCHEMBL9677497 | 0.85 | GRM2 (0.63) | GRM2SIGMAR1ATMPIK3C3ATR | |
| SCHEMBL9678594 | 0.84 | MAOA (0.54) | GRM2ATMPIK3C3ATRPRKDC | |
| SCHEMBL9677627 | 0.83 | GRM2 (0.54) | GRM2SIGMAR1ATMPIK3C3ATR | |
| SCHEMBL9678678 | 0.83 | GRM2 (0.54) | GRM2SIGMAR1ATMPIK3C3ATR | |
| SCHEMBL9678951 | 0.82 | SIGMAR1 (0.54) | GRM2SIGMAR1 | |
| SCHEMBL9676125 | 0.82 | SIGMAR1 (0.51) | GRM2SIGMAR1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300272-B1 | OXAZOLIDINONES | MERCK PATENT GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |
| US-4970217-A | NEUROLEPTIC | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-11-13 | — | — | US | disclosed |
| EP-0300272-A1 | Oxazolidinones | MERCK PATENT GmbH (DE) | 1989-01-25 | — | — | EP | disclosed |