Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681811 | 0.74 | NPC1 (0.44) | NPC1KDM4EKMT2AHSD17B10MEN1 | |
| SCHEMBL28308539 | 0.73 | PRNP (0.45) | NPC1KDM4EHSD17B10MAPTALDH1A1 | |
| SCHEMBL5117887 | 0.73 | NPC1 (0.53) | NPC1KDM4EKMT2AHSD17B10MEN1 | |
| SCHEMBL9455514 | 0.71 | KDM4E (0.52) | NPC1KDM4EHSD17B10MAPTALDH1A1 | |
| SCHEMBL9682063 | 0.71 | NPC1 (0.41) | NPC1KDM4EKMT2AMEN1MAPT | |
| SCHEMBL6333760 | 0.70 | ALDH1A1 (0.59) | NPC1KDM4EPDE4DKMT2AMEN1 | |
| SCHEMBL5114888 | 0.70 | NPC1 (0.50) | NPC1KDM4EPDE4DKMT2AHSD17B10 | |
| SCHEMBL6074387 | 0.69 | FGFR4 (0.40) | FGFR4CYP19A1CYP11B2PDE4DKMT2A | |
| Acetic Acid SCHEMBL5125173 | 0.68 | KDM4E (0.46) | NPC1KDM4EKMT2AHSD17B10MEN1 | |
| SCHEMBL5045112 | 0.68 | MAPT (0.62) | KDM4ECYP19A1CYP11B2PDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481802-A1 | Hydroxylated inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | disclosed |