Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 8/20 | 0.37 |
| ▸ | KCNE1 | P15382 | 7/20 | 0.37 |
| ▸ | KCNQ1 | P51787 | 7/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9199615 | 0.89 | ABCB1 (0.39) | ABCC9KCNE1KCNQ1NPSR1CYP3A4 | |
| SCHEMBL9199563 | 0.86 | ABCC9 (0.38) | ABCC9KCNE1KCNQ1CYP1A2CYP2D6 | |
| SCHEMBL9197589 | 0.84 | MAPT (0.43) | ABCC9MEN1KMT2A | |
| SCHEMBL9195596 | 0.84 | ABCC9 (0.52) | ABCC9KCNE1KCNQ1MEN1CYP1A2 | |
| SCHEMBL9197886 | 0.84 | ABCC9 (0.42) | ABCC9KCNE1KCNQ1NPSR1MEN1 | |
| SCHEMBL9192434 | 0.82 | KCNA5 (0.39) | ABCC9KCNA5 | |
| SCHEMBL9195248 | 0.77 | SMN1; SMN2 (0.43) | KCNE1KCNQ1NPSR1MEN1KMT2A | |
| SCHEMBL9194242 | 0.77 | TP53 (0.46) | ABCC9KCNE1KCNQ1NPSR1MEN1 | |
| SCHEMBL9682025 | 0.76 | LMNA (0.34) | ABCC9KCNE1KCNQ1KCNA5 | |
| SCHEMBL9195978 | 0.74 | ABCB1 (0.56) | ABCC9CYP1A2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0406656-B1 | Chroman derivatives | MERCK PATENT GMBH (DE) | 1995-01-11 | — | — | EP | disclosed |
| US-5112839-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-05-12 | — | — | US | disclosed |
| EP-0406656-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-01-09 | — | — | EP | disclosed |