Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | GAA | P10253 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | IDH1 | O75874 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846236 | 0.88 | MAPT (0.38) | MAPTGAALMNATDP1L3MBTL1 | |
| SCHEMBL9168694 | 0.85 | PDE3B (0.42) | MAPTGAALMNATDP1L3MBTL1 | |
| SCHEMBL9680861 | 0.84 | SLC2A1 (0.38) | MAPTGAALMNATDP1L3MBTL1 | |
| SCHEMBL9681773 | 0.84 | MAPT (0.38) | MAPTGAALMNATDP1L3MBTL1 | |
| SCHEMBL9680359 | 0.83 | MAPT (0.34) | MAPTGAAKDM4EAPAF1RECQL | |
| SCHEMBL9682064 | 0.83 | MAPT (0.34) | MAPTGAAKDM4EAPAF1RECQL | |
| SCHEMBL9681421 | 0.82 | MAPT (0.37) | MAPTGAALMNAMAPK1KDM4E | |
| SCHEMBL9846165 | 0.79 | PDE3B (0.41) | MAPTGAALMNATDP1L3MBTL1 | |
| SCHEMBL9681299 | 0.78 | MAPT (0.35) | MAPTGAALMNAMAPK1KDM4E | |
| SCHEMBL9682808 | 0.77 | PDE10A (0.34) | MAPTLMNATSHRMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481802-A1 | Hydroxylated inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | claimed |
| EP-0481802-A1 | Hydroxylated inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | disclosed |
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |