Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 3/20 | 0.31 |
| ▸ | ASPH | Q12797 | 1/20 | 0.31 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681425 | 0.84 | CYP2C9 (0.33) | PDE10AKDM4EMAPTAPAF1RECQL | |
| SCHEMBL9682064 | 0.81 | MAPT (0.34) | PDE10AKDM4EMAPTAPAF1RECQL | |
| SCHEMBL9680359 | 0.81 | MAPT (0.34) | PDE10AKDM4EMAPTAPAF1RECQL | |
| SCHEMBL9681773 | 0.79 | MAPT (0.38) | KDM4EMAPTAPAF1RECQLALDH1A1 | |
| SCHEMBL9681442 | 0.79 | KDM4E (0.36) | PDE10AKDM4EMAPTAPAF1RECQL | |
| SCHEMBL9681915 | 0.78 | PDE10A (0.40) | PDE10AKDM4EMAPTAPAF1RECQL | |
| SCHEMBL9681383 | 0.78 | NPC1 (0.34) | KDM4EMAPTAPAF1RECQLPOLB | |
| SCHEMBL9682084 | 0.78 | MAPT (0.36) | KDM4EMAPTAPAF1RECQLPOLB | |
| SCHEMBL9680853 | 0.77 | MAPT (0.38) | KDM4EMAPTAPAF1RECQLALDH1A1 | |
| SCHEMBL9680861 | 0.73 | SLC2A1 (0.38) | KDM4EMAPTAPAF1RECQLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0481802-A1 | Hydroxylated inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | claimed |
| EP-0481802-A1 | Hydroxylated inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | disclosed |