Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | DUT | P33316 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14488158 | 0.85 | POLB (0.46) | NPC1MITFLMNATP53RAB9A | |
| SCHEMBL9752623 | 0.85 | POLB (0.48) | NPC1MITFLMNATP53RAB9A | |
| SCHEMBL31424843 | 0.83 | SMN1; SMN2 (0.46) | NPC1MITFLMNATP53RAB9A | |
| SCHEMBL15424625 | 0.81 | L3MBTL1 (0.57) | NPC1MITFLMNATP53RAB9A | |
| SCHEMBL200911 | 0.79 | NPC1 (0.41) | NPC1MITFLMNATP53RAB9A | |
| SCHEMBL9752573 | 0.76 | L3MBTL1 (0.58) | NPC1MITFLMNATP53RAB9A | |
| SCHEMBL9752736 | 0.73 | L3MBTL1 (0.60) | NPC1MITFLMNATP53RAB9A | |
| SCHEMBL9752671 | 0.73 | L3MBTL1 (0.51) | NPC1MITFLMNATP53RAB9A | |
| SCHEMBL22842957 | 0.71 | L3MBTL1 (0.54) | NPC1MITFLMNATP53RAB9A | |
| SCHEMBL9394796 | 0.70 | L3MBTL1 (0.51) | NPC1MITFLMNATP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112839-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-05-12 | — | — | US | disclosed |
| EP-0406656-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-01-09 | — | — | EP | disclosed |