Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.35 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681557 | 1.00 | MEN1 (0.38) | MEN1LMNAKMT2ATHRBBLM | |
| SCHEMBL9681733 | 0.82 | MAPT (0.49) | MEN1LMNAKMT2ATHRBBLM | |
| SCHEMBL9681724 | 0.82 | MAPT (0.49) | MEN1LMNAKMT2ATHRBBLM | |
| SCHEMBL9680999 | 0.80 | MEN1 (0.42) | MEN1LMNAKMT2ATHRBBLM | |
| SCHEMBL9681007 | 0.80 | MEN1 (0.42) | MEN1LMNAKMT2ATHRBBLM | |
| SCHEMBL9737066 | 0.79 | ALDH1A1 (0.38) | MEN1LMNAKMT2AMAPTALDH1A1 | |
| SCHEMBL5606940 | 0.73 | MIF (0.46) | MEN1LMNAKMT2AMAPTALDH1A1 | |
| SCHEMBL9680642 | 0.71 | MAPT (0.47) | MEN1LMNAKMT2ATHRBBLM | |
| SCHEMBL29262005 | 0.70 | MEN1 (0.36) | MEN1LMNAKMT2ATHRBBLM | |
| SCHEMBL28562985 | 0.70 | HSD11B1 (0.41) | MEN1LMNAKMT2APLIN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162345-A | Dihydropyridinedicarboxylate Derivatives | GLAXO, S.P.A. (IT) | 1992-11-10 | — | — | US | disclosed |
| US-5091395-A | Hypotensive agents | GLAXO S.P.A. (IT) | 1992-02-25 | — | — | US | disclosed |
| EP-0226271-B1 | 1,4-DIHYDROPYRIDINE COMPOUNDS AND THEIR PREPARATION AND PHARMACEUTICAL FORMULATION | GLAXO S.p.A. (IT) | 1990-11-22 | — | — | EP | disclosed |
| EP-0226271-A1 | 1,4-Dihydropyridine compounds and their preparation and pharmaceutical formulation | GLAXO S.p.A. (IT) | 1987-06-24 | — | — | EP | disclosed |