Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 4/20 | 0.65 |
| ▸ | KHK | P50053 | 6/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAT1A | Q00266 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9681259 | 0.91 | MAT2A (0.59) | MAT2AKHKTP53KMT2AKDM4E | |
| Fumaric Acid SCHEMBL9681264 | 0.91 | MAT2A (0.59) | MAT2AKHKTP53KMT2AKDM4E | |
| SCHEMBL9680590 | 0.85 | KHK (0.58) | MAT2AKHKKMT2A | |
| SCHEMBL9681273 | 0.85 | KHK (0.57) | MAT2AKHKTP53KMT2AKDM4E | |
| SCHEMBL10582090 | 0.84 | MAT2A (0.47) | MAT2AKHKALDH1A1NPSR1MAT1A | |
| SCHEMBL6125292 | 0.84 | KHK (0.56) | MAT2AKHKHRH4KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9681879 | 0.84 | KHK (0.56) | MAT2AKHKTP53KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL9682507 | 0.84 | KHK (0.57) | MAT2AKHKKMT2AHTR6 | |
| Hydrochloric Acid SCHEMBL9682152 | 0.82 | KHK (0.54) | MAT2AKHKHRH4KDM4EALDH1A1 | |
| SCHEMBL22093667 | 0.79 | MAT2A (1.00) | MAT2AMAT1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4999356-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-03-12 | — | — | US | claimed |
| US-5134236-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-07-28 | — | — | US | disclosed |
| US-4999356-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-03-12 | — | — | US | disclosed |
| EP-0302423-A2 | 1-Phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-02-08 | — | — | EP | disclosed |