Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.43 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.42 |
| ▸ | MAT2A | P31153 | 4/20 | 0.59 |
| ▸ | KHK | P50053 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GMNN | O75496 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9681264 | 1.00 | MAT2A (0.59) | MAT2AKHKRAB9AMAPK8ADRA2A | |
| SCHEMBL9681923 | 0.91 | MAT2A (0.65) | MAT2AKHKRAB9AKDM4EALDH1A1 | |
| Fumaric Acid SCHEMBL9681236 | 0.80 | LMNA (0.44) | KHKRAB9AADRA2AKDM4EALDH1A1 | |
| Fumaric Acid SCHEMBL9681228 | 0.80 | LMNA (0.44) | KHKRAB9AADRA2AKDM4EALDH1A1 | |
| Fumaric Acid SCHEMBL9680687 | 0.77 | KDM4E (0.54) | KHKADRA2ADRD4KDM4EALDH1A1 | |
| Fumaric Acid SCHEMBL9680682 | 0.77 | KDM4E (0.54) | KHKADRA2ADRD4KDM4EALDH1A1 | |
| SCHEMBL9681273 | 0.77 | KHK (0.57) | MAT2AKHKHTR2AKDM4ETP53 | |
| SCHEMBL9680590 | 0.77 | KHK (0.58) | MAT2AKHKMAPTKMT2AMAPK1 | |
| SCHEMBL10582090 | 0.77 | MAT2A (0.47) | MAT2AKHKALDH1A1MAT1AMAPK1 | |
| SCHEMBL6125292 | 0.76 | KHK (0.56) | MAT2AKHKKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5134236-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-07-28 | — | — | US | disclosed |
| US-4999356-A | Analgesics, antidepressants, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-03-12 | — | — | US | disclosed |
| EP-0302423-A2 | 1-Phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-02-08 | — | — | EP | disclosed |