Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 20/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9683786 | 0.90 | CA2 (0.61) | CA2CA1 | |
| SCHEMBL9682638 | 0.87 | CA2 (0.58) | CA2CA12CA1CA3AR | |
| SCHEMBL7520641 | 0.78 | CA2 (0.62) | CA2CA1CA4 | |
| SCHEMBL7520645 | 0.77 | CA2 (1.00) | CA2CA4 | |
| SCHEMBL9683134 | 0.73 | CA2 (0.51) | CA2CA12CA1CA3AR | |
| SCHEMBL9682080 | 0.72 | CA2 (1.00) | CA2 | |
| SCHEMBL9682085 | 0.70 | CA2 (0.61) | CA2CA1CA4 | |
| SCHEMBL7526891 | 0.70 | CA2 (1.00) | CA2 | |
| SCHEMBL9682149 | 0.65 | CA2 (1.00) | CA2 | |
| SCHEMBL9682708 | 0.65 | CA2 (0.81) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0479480-A2 | Substituted thieno(2,3-B)(1,4)thiazine-6-sulfonamides as antiglaucoma agents | MERCK & CO. INC. (US) | 1992-04-08 | — | — | EP | claimed |
| US-5093332-A | SUBSTITUTED THIENO(2,3-B)(1,4)THIAZINE-6-SULFONAMIDES AS ANTIGLAUCOMA AGENTS | MERCK & CO., INC. (US) | 1992-03-03 | — | — | US | claimed |
| EP-0479480-A2 | Substituted thieno(2,3-B)(1,4)thiazine-6-sulfonamides as antiglaucoma agents | MERCK & CO. INC. (US) | 1992-04-08 | — | — | EP | disclosed |
| US-5093332-A | SUBSTITUTED THIENO(2,3-B)(1,4)THIAZINE-6-SULFONAMIDES AS ANTIGLAUCOMA AGENTS | MERCK & CO., INC. (US) | 1992-03-03 | — | — | US | disclosed |