Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 11/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9682080 | 0.90 | CA2 (1.00) | CA2HSD17B10GLAHTTTSHR | |
| SCHEMBL7525460 | 0.81 | CA2 (1.00) | CA2HTTKDM4ETP53 | |
| SCHEMBL9740275 | 0.73 | CA2 (0.58) | CA2 | |
| SCHEMBL9683786 | 0.72 | CA2 (0.61) | CA2 | |
| SCHEMBL9683906 | 0.66 | CA2 (0.55) | CA2 | |
| SCHEMBL9682131 | 0.65 | CA2 (0.61) | CA2 | |
| SCHEMBL9682119 | 0.63 | CA2 (1.00) | CA2HTT | |
| SCHEMBL9682638 | 0.63 | CA2 (0.58) | CA2TSHR | |
| SCHEMBL7519623 | 0.62 | CA2 (1.00) | CA2 | |
| SCHEMBL9683126 | 0.59 | CA2 (0.70) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0479480-A2 | Substituted thieno(2,3-B)(1,4)thiazine-6-sulfonamides as antiglaucoma agents | MERCK & CO. INC. (US) | 1992-04-08 | — | — | EP | claimed |
| US-5093332-A | SUBSTITUTED THIENO(2,3-B)(1,4)THIAZINE-6-SULFONAMIDES AS ANTIGLAUCOMA AGENTS | MERCK & CO., INC. (US) | 1992-03-03 | — | — | US | claimed |
| EP-0479480-A2 | Substituted thieno(2,3-B)(1,4)thiazine-6-sulfonamides as antiglaucoma agents | MERCK & CO. INC. (US) | 1992-04-08 | — | — | EP | disclosed |
| US-5093332-A | SUBSTITUTED THIENO(2,3-B)(1,4)THIAZINE-6-SULFONAMIDES AS ANTIGLAUCOMA AGENTS | MERCK & CO., INC. (US) | 1992-03-03 | — | — | US | disclosed |