Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11572195 | 0.89 | MAPK1 (0.47) | MEN1CYP2C9KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL30250167 | 0.87 | AKR1C1 (0.47) | MEN1CYP2C9KMT2AOPRM1RAB9A | |
| SCHEMBL30877933 | 0.85 | AKR1C1 (0.46) | MEN1CYP2C9KMT2AOPRM1AKR1C1 | |
| SCHEMBL9821032 | 0.85 | ESR2 (0.53) | CYP2C9RAB9ANPC1LMNACYP2D6 | |
| SCHEMBL14379104 | 0.82 | OPRL1 (0.46) | OPRM1RAB9ANPC1AKR1C1AKR1C3 | |
| SCHEMBL7814234 | 0.81 | RAB9A (0.42) | OPRM1RAB9ANPC1AKR1C1AKR1C3 | |
| SCHEMBL10477046 | 0.81 | AKR1C1 (0.63) | KMT2AOPRM1RAB9ANPC1AKR1C1 | |
| Bicarbonate SCHEMBL7575333 | 0.78 | MEN1 (0.60) | MEN1CYP2C9KMT2AOPRM1AKR1C1 | |
| SCHEMBL5156523 | 0.78 | OPRL1 (0.62) | OPRM1 | |
| SCHEMBL11573415 | 0.78 | SMN1; SMN2 (0.45) | MEN1CYP2C9KMT2AMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175319-A | Antiprotozoa agent, useful for treating malaria, theileriosis, coccidiosis and prophylaxix | BURROUGHS WELLCOME CO. (US) | 1992-12-29 | — | — | US | disclosed |
| US-5053432-A | Antiprotozoa agents; treatment of malaria | BURROUGHS WELLCOME CO. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0123238-B1 | NAPHTHOQUINONE DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1987-06-10 | — | — | EP | disclosed |
| EP-0123238-A2 | Naphthoquinone derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-10-31 | — | — | EP | disclosed |